The Chemical Ingredient Of Acetylsalicylic Acid Essay

Acetylsalicylic acid is the active pharmaceutical ingredient that is found in aspirin and is used to treat inflammation, pain and fever. It is created by an esterification reaction of salicylic acid with acetic anhydride in the presence of an acid catalyst. At the end of the reaction, a product and unreacted salicylic acid and acid catalyst was created. The product contains impurities, such as acetic anhydride and salicylic acid, which needs to be removed. Crystallization, a technique used to purify substances, produces crystals and the impurities get filtered under the vacuum. Adding water after the crystals are made but before the crystals are vacuumed helps to purify the crystals and get rid of some impurities. Melting the crystals can determine the purity of the product that was made. When performing the experiment, salicylic acid will be in a flask and in a water bath. It is important that it sits in the water bath for at least eight minutes but no more than ten minutes. If it i s in the water bath for more than ten minutes, the salicylic acid could decompose. The purpose of this experiment was to determine the presence of salicylic acid and starch in acetylsalicylic acid. The presence of salicylic acid can be determined by performing a ferric chloride test. The presence of starch can be determined by performing an iodine test. In order to find the percent yield, the following formula was used: Percent yield= (Mass of product obtained experimentally)/(mass of productShow MoreRelatedHistorical Developments Relevant For Aspirin Essay1313 Words   |  6 PagesSalicylic acid, which is found in Aspirin, which made the patients feel better while healing them, similar to the modern Aspirin. Further along in Human history we know that Edward Stone discovered and isolated the key chemical in the Willow bark/leaves called Salicylic Acid. The problem with the Salicylic acid was that it was extremely tough on stomachs and could cause nausea and vomiting, hence the next step in developing Aspirin was to find an effective buffer that would make the Salicylic acid easierRead MoreThe Active Pharmaceutical Ingredient Of Aspirin909 Words   |  4 Pagespharmaceutical ingredient in aspirin is acetylsalicylic acid can be synthesized through a reaction between acetic anhydride and salicylic acid. In the presence of an acid catalyst, the esterfication reaction of salicylic acid with acetic a nhydride occurs. This reaction is done in a 50 °C water bath for eight minutes. A higher temperature and longer time would cause the product to decompose. Once acetylsalicylic acid is formed, it needs to be separated from the acid catalyst, unreacted salicylic acid, and unreactedRead MorePharmaceutical Industry : Chemical Synthesis Essay2219 Words   |  9 PagesPharmaceutical Industry: Chemical Synthesis Production of Acetylsalicylic Acid I. Introduction Pharmaceutical industry is one of the biggest industry in the world as it involves drugs and medications - something that is very stable in terms of demand. This can be proven by the amount of sales as of 2012. Figure 1.1 shows the breakdown of the market of the pharmaceutical industry worldwide. However, aside from the production and synthesis of drugs and medications, the industry is also involvedRead MoreThe Production and Manufacture of Aspirin Essay example741 Words   |  3 Pagesof production is known as slugging or dry-granulation. In this method, corn starch is mixed with pure water and is then heated and stirred till a transparent paste is formed. This paste is then mixed with lubricant and the active ingredient, which is acetylsalicylic acid in a machine called and Glenn mixer. This removes any air trapped in the mixture. This mixture is then separated into units known as slugs. Next, large batches of these slugs are filtered through a machine called a Fitzpatrick MillRe ad MoreSynthesis of Aspirin1618 Words   |  7 PagesSypnopsis In this experiment, acetylsalicylic acid was synthesized from the acidification of salicylic acid and acetic anhydride. The objective was to convert a specific amount of salicylic acid into the same amount of aspirin that was high in purity. Furthermore, the other objectives were to enable students to conduct the synthesis of aspirin, reinforce skills or recrystallisation and the technique of melting point determination. The amount of each compound should be the same because there isRead MorePreparation of Aspirin and Determination of the Melting Point1445 Words   |  6 PagesManila, Philippines ABSTRACT This experiment involved three steps: synthesis of aspirin, isolation and purification, and the estimation of purity of the final product. The synthesis involved the reaction of salicylic acid and acetic anhydride in the presence of a catalyst, phosphoric acid, H3PO4. When the aspirin was prepared, it was isolated and filtered. The percentage yield of the synthesis was calculated to be 78.42%. The experimental melting point range of aspirin was determined to be 122 -132 °CRead MoreOrganic Chemistry Of Chemical Reactions1998 Words   |  8 Pagescreated such as in the manufacture of plastics, polymers, fuels, soaps, detergents, drugs and medicines. These, if carefully designed, have important properties for the improvement of mankind. One such example of manipulating organic compounds through chemical reactions is the development of Aspirin and later, other associated analgesics or non-steroidal anti-inflammatory drugs. Brady Grindrod 2014 Organic chemistry, often termed the ‘chemistry of design’, is the chemistry of carbon compounds. It dealsRead MoreSynthesis and Characterization of Aspirin Product Identity and Purity After synthesizing a1000 Words   |  4 PagesIdentity and Purity After synthesizing a chemical, especially a drug, it is important to confirm the identity and purity of the product. You will perform three tests to examine the identity and purity of the aspirin that you synthesized. One test will detect the presence of leftover salicylic acid in the synthesized aspirin and allow you to determine its concentration. Government regulations stipulate that commercial aspirin must not contain residual salicylic acid since it is irritating to the mouthRead MoreAspirin And Plants : Aspirin967 Words   |  4 PagesAspirin And Plants What is Aspirin? Acetylsalicylic acid, commonly known as aspirin, has a chemical formula of C9H804. Aspirin is one of the first drugs in the world that came to a common use with about 35,000 metric tons that are annually used and consumed by people all over the world. Aspirin is commonly used to relieve people from pain of headaches and reduces the temperatures of fevers. Aspirin is also used to sooth a scratchy throat, relieving pain from bug-bites, wiping away rustRead MoreLab Report On The Mass Of Actual Aspirin ( Acetylsalicylic Acid )2105 Words   |  9 PagesAbstract: This experiment utilizes skills of titration in order to find the percent mass of actual aspirin (acetylsalicylic acid) in store-bought aspirin. Two steps and two kinds of titrations are used. First, approximately 0.1 M NaOH solution was standardized using titration with KHP. KHP was used because it does not absorb moisture when it is stored, and it is soluble in water. The reaction that takes place in this reactio n is a 1:1 mole ratio reaction. The titration determines the volume